Hiroshi MIZUSHIMA Ph.D

Papers in International Journals

Homma H., Kobayashi T., Chiba N., Karasawa K., Mizushima H., Kudo I., Inoue K., Ikeda H., Sekiguchi M., Nojima S. The DNA sequence encoding pldA gene, the structural gene for detergent-resistant phospholipase A of E. coli. J.Biochem. 96(6) p.1655-64, (1984.12) [MEDLINE]

Kobayashi T., Kudo I., Karasawa K., Mizushima H., Inoue K., Nojima S. Nucleotide sequence of the pldB gene and characteristics of deduced amino acid sequence of lysophospholipase L2 in Escherichia coli. J.Biochem. 98(4) p.1017-25, (1985.10) [MEDLINE]

Mizushima H., Kudo I., Horigome K.,Murakami M., Hayakawa M.,Kim D.K., Kondo E.,Tomita M.,Inoue K. Purification of rabbit platelet secretory phospholipase A2 and its characteristics. J.Biochem. 105(4) p.520-5, (1989.4) [MEDLINE]

Komada M., Kudo I., Mizushima H., Kitamura N., Inoue K.　Structure of cDNA coding for rat platelet phospholipase A2. J.Biochem. 106(4) p.545-7, (1989.10) [MEDLINE]

Kuchino Y., Mizushima H., Schroder H.C., Muller W.E.G Abnormal expression of a host cell tRNA gene by retrovirus infection: effect of Avarol. Archives of AIDS Research 4 (1990)

Kuchino Y., Mizushima H., Nishimura S. Transfer RNAs and other soluble RNAs 「Nucleotide Sequence analysis and identification of modified nucleotides of tRNA.」CRC press (1990)

Kim D-K., Kudo I., Fujimori Y., Mizushima H., Masuda M., Kikuchi R., Ikizawa K., Inoue K. Detection and subcellular localization of rabbit platelet phospholipase A2 which preferentially hydrolyzes an arachidonyl residue. J.Biochem. 108(6) p.903-6 (1990.12) [MEDLINE]

Karasawa K., Kudo I., Kobayashi T., Homma H., Chiba N., Mizushima H., Inoue K., Nojima S. Lysophospholipase L1 from Escherichia coli K-12 overproducer. J.Biochem. 109(2), p288-293, (1991.2) [MEDLINE]

Mori H., Hara S., Mizushima H., Kudo I., Sato Y., Inoue K. Extracellular phospholipase A2 detected at inflamed sites in rats does not originate from platelets. Agents and Actions 32(3-4), p266-269, (1991.3) [MEDLINE]

Masuda M., Kudo I., Naito M., Mizushima H., Inoue K. Phospholipid composition of rat megakaryocytes and its rearrangement in platelets. Biochemica et Biophysica Acta 1083(3), p.235-242, (1991.6) [MEDLINE]

Nemoto F., Okazaki T., Mizushima H., Muller W.E.G., Kuchino Y. Nucleotide sequence of the human tRNAUUGGln gene. Nucl.Acids Res. 19(10), p.2779, (1991.5) [MEDLINE]

Heinz C.Shroder, D.Ugarkovic, W.E.G.Muller, H Mizushima, F.Nemoto, Y.Kuchino, Increased expression of UAG suppressor tRNA in Aged Mice: Consequences for Retroviral Gene Expression, Eur.J.Gerontol. 8, p.452-457, (1992)

H.Mizushima, Y.Kuchino Integration of Local Area Network system in National Cancer Center, and study for network-aided genetic information analysis system. Genome Informatics Workshop 92 (1992.12) [Abstract]

Bruenger,E., Kowalak,J., Kuchino,Y., McCloskey,J., Mizushima,H., Stettler,K., Crain,P. : 5S rRNA modification in the hyperthermophilic archaea Sulfolobus solfataricus and Pyrodictium occultum. FASEB J., 7(1), p.196-200, (1993.1) [MEDLINE]

H.Mizushima, Y.Kuchino Development of a genetic information system for institute engaged in molecular biology. Genome Informatics Workshop IV (1993)

Nemoto F, Kohda T, Mizushima H, Yoshikura H, Schroder HC, Muller WE, Kuchino Y. : Characterization and transcriptional regulation of rat glutamine tRNA-encoding genes: repression of tRNA(UUGGln) synthesis. Gene 145(2) p.189-96 (1994.8) [MEDLINE]

Mizushima H, Hayashi K. Establishment of Transcription Factor Database and Human Mutaion Database. Genome Informatics Workshop 1994. 5 p.142-143. (1994.12) [Abstract]

Mizushima H., Wakao F., Mukai K., Sekiguchi R., Hojo F., Yamaguchi N., Ishikawa K.B., Uchiyama E., Akiyama M., Yamashiro K., Wada S., Nishida A., Kakizoe T., Abe K.: Development of a medical network systems in Japan. World Congress on Telemedicine, Programme and Abstracts. 1995 p.258-259 (1995.11)

Mizushima H., Wakao F., Ishikawa K.B., Uchiyama E., Akiyama M., Abe K., : Multimedia Network for Telemedicine. American Medical Informatics Association Spring Congress Abstract Book. p.39,(1996.6)

Okazaki T., Kaizawa M., Mizushima H., :Establishment and Management of Transcription Factor Database TFDB. Genome Informatics 1996. p.218-219, (1996.12)

Ushida C., Muramatsu T., Mizushima H., Ueda T., Watanabe K., Stettler K.O., Crain P.F., McCloskey J.A., Kuchino Y., :Structural feature of the initiator tRNA gene from Pyrodictium occultum and the thermal stability of its gene product, tRNAiMet. Biochimie 78 p.847-855,(1996) [MEDLINE]

Mizushima H., Uchiyama E., Wakao F., Akiyama M., Abe K. Nationwide Cancer Information Network in Japan. The 3rd International Conference on the Medical Aspects of Telemedicine Program and Book of Abstract p.1082 (1997.5)

Nagata H., Mizushima H. NCC_image: New remote collaboration telemedicine system over the Internet by using Java The 3rd International Conference on the Medical Aspects of Telemedicine Program and Book of Abstract p.180 (1997.5)

Mizushima H., Uchiyama E, Akiyama M, Yamamoto R, and Tatsumi H. Linking medical network together for secure medical internet. Proceedings of Asia-Pacific Medical Informatics Association Meeting in Sydney (1997)

Uchiyama E., Mizushima H., Wakao F. Cancer Center Network Multipoint TeleConference System. Proceedings of the Second China-Japan Joint Symposium on Medical Informatics. pp.155-157 (1997.11)

Kaizawa M., Okazaki T., Mizushima H., :Establishment of Transcription Factor Database TFDB Maintenance System. Genome Informatics 1997. p.292-293,(1997.12) [PDF]

H.Mizushima, E.Uchiyama, M.Akiyama, R.Yamamoto, H.Tatsumi. Medical Internet Exchange Project in Japan. MEDINFO98(B.Cesnik et.al. Eds, IOS Press. Amsterdam) pp.417-419. (1998.8) [MEDLINE]

Y.Matsuno H.Mizushima et.al., Pathology teleconferencing between expert institutuins over the internet. In United States and Canadian Academy of Pathology in Press

Nagata H, Mizushima H, World wide microscope: new concept of internet telepathology microscope and implementation of the prototype. MEDINFO'98(B.Cesnik et.al. Eds, IOS Press. Amsterdam) 9(1) p.286-9 (1998.8) [MEDLINE]

Nagata H., Mizushima H. A remote collaboration system for telemedicine using the Internet. Journal of Telemedicine and Telecare 4(2) p.89-94 (1998) [MEDLINE]

Abe K., Wakao F., Oyama H., Mizushima H., Shinkai T., Ishikawa K., Watanabe T., Moriyama N., Yamaguchi N.; Information technology at the National Cancer Center. Japanese Journal of Clinical Oncology. 28(9) p.527-530 (1998,9)[Full Text] [MEDLINE]

Shinkai T., Abe K., Mizushima H., Wakao F., Ishikawa K., Watanabe T.,Kodama T., Yamaguchi N., Ebihara S.; Cancer Information from the National Cancer Center,Japan. Japanese Journal of Clinical Oncology 28(12), p.717-720, (1998,12) [Full Text] [MEDLINE]

Kaizawa M., Watanabe S., Nobukuni T., Horikoshi M., Handa H., Kuchino Y., Sekiya T., Mizushima H. Maintenance of Transcription Factor Database TFDB by TFDB Maintenance System. Genome Informatics 1998(Miyano S. Takagi T. Eds: ISSN:0919-9454) pp316-318 (1998.12)[PDF]

Mizushima H., Cancer Information Network; Internal Medicine 38(2) p.192-194, (1999,2) [MEDLINE]

Kaizawa M., Watanabe S., Nobukuni T., Horikoshi M., Handa H., Kuchino Y., Sekiya T., Mizushima H. Maintenance of Transcription Factor Database TFDB. Genome Informatics 1999(Asai K. Miyano S. Takagi T. Eds: ISSN:0919-9454) pp269-271 (1999.12)[PDF]

Mizushima H., Uchiyama E., Nagata H., Yamaguchi N.; Telemedicine Comes of Age. Japanese Journal of Clinical Oncology 30(1), p.3-6, (2000,1) [MEDLINE] [Full Text]

Nagata H., Tanaka E., Hatsuta M., Mizushima H, Tanaka H.; Molecular Virtual Reality System with Force Feedback Device ICAT 2000 p161-166 (2000.10) [PDF]

Chen YZ, Hayashi Y, Wu JG, Takaoka E, Maekawa K, Watanabe N, Inazawa J Hosoda F, Arai Y, Ohki M, Mizushima H Morohashi A, Ohira M, Nakagawara A, Liu SY, Hoshi M, Horii A, Soeda E.; A BAC-based STS-content map spanning a 35Mb region of human chromosome 1p35-36. Genomics Vol.74. pp55-70 (2001) [PubMed]

Mizushima H, Uchiyama E, Nagata H, Matsuno Y, Sekiguchi R, Ohmatsu H, Hojo F, Shimoda T, Wakao F, Shinkai T, Yamaguchi N, Moriyama N, Kakizoe T, Abe K, Terada M.; Japanese experience of telemedicine in oncology. International Journal of Medical Informatics. Vol.61 p207-215 (2001) [PubMed]

Mizushima H., Nagata H., Tanaka E., Hatsuta M., Tanaka H.; Virtual Reality System using Force Feedback Device for Molecular Modeling. MEDINFO2001 (V.Patel et al. Eds. Amsterdam:IOS Press pp.975-978 (2001) [PubMed]

Nagata H., Mizushima H., Tanaka H.; Concept and prototype of protein-ligand docking simulator with force feedback technology. Bioinformatics Vol.18 No.1 p.140-146 (2002) [Abstract/pdf] [PubMed]

Mizushima H, Ichikawa H, Ohki M. ANALYSYS TOOL FOR FINDING TRANSCRIPTION REGULATORY ELEMENTS, USING TRANSCRIPTION FACTOR DATA BASE (TFDB). Proceedings of the Third International Conference on Bioinformatics of Genome Regulation and Structure. 1, p.37-39 (2002.7)

Mizushima H, Tanaka H, Hatsuta M, Arai D, Nagata H. ; Molecular Modeling using Virtual Reality with Force Feed Back. Conference Proceedings of ISMB03 (2003.7)

Yamashiro K, Kawamura N, Matsubayashi S, Dota K, Suzuki H, Mizushima H, Wakao F, Azumi N. ; Telecytology in Hokkaido Island, Japan: results of primary telecytodiagnosis of routine cases. Cytopathology. 15(4) p.221-227. (2004.8) [PubMed]

Mizushima H, Takatsu M, Kawahara K, Yoshida T. ; Analysis Tool for Finding Transcription Regulatory Elements, using Transcription Factor Database (TFDB) and Genome Comparison. MEDINFO 2004 (IOS Press, Netherlands) (2004.8)

Sugawara H, Mizushima H, Kano T, Shigemoto Y, Hashimoto Y, Tomabechi I, Ikawa M, Sakagami N, Oroguchi T, Katagiri T. ; Polymorphism Markup Language (PML) for the interoperability of data on SNPs and other sequence variations. Genome Informatics P170 (2004.12)

Okada I, Ohnishi T, Nagata H, Tanaka H, Mizushima H. ; Portable virtual reality system using haptic device and naked eye 3D display, for molecular modeling. Conference Proceedings of ISMB05 (2005.7)

Ohashi K, Gomi Y, Nogawa H, Mizushima H, Tanaka H. ; Development of Secured Medical Network with TCP2 for Telemedicine. Stud Health Technol Inform.;116, p.397-402.(2005) [PubMed]

Okada I, Ohnishi T, Nagata H, Tanaka H, Mizushima H. ; Improvement of Portable virtual reality system with haptic device for molecular modeling and education. Conference Proceedings of ISMB06 (2006.7)

Ichikawa H, Tanabe K, Mizushima H, Hayashi Y, Mizutani S, Ishii E, Hongo T, Kikuchi A, Satake M. ; Common gene expression signatures in t(8;21)- and inv(16)-acute myeloid leukaemia. Br J Haematol. 135(3)p.336-47 (2006.11) [PubMed]

Mima S, Ushijima H, Hwang HJ, Tsutsumi S, Makise M, Yamaguchi Y, Tsuchiya T, Mizushima H, Mizushima T. ; Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. FEBS Lett. 581(7) p.1457-63 (2007.4) [PubMed]

Mizushima H, Mogushi K, Ohashi W, Araki E, Nishibori M, Arii S, Sugihara K, Miki Y, Inazawa J, Tanaka H. ; TMDU Clinical Omics Database Project - Integration of OMICS data and Clinical Information. Conference Proceedings of ISMB07 p.I79 (2007.7)

Fujisaki A, Araki E, Mizushima H, Tanaka H. ; Development of TMDU Clinical Omics Database. Conference Proceedings of ISMB07 p.N65 (2007.7)

Ohashi W, Mizushima H, Tanaka H. ; Proposal of Efficient Clinical Trials by using the Genomic Information. MEDINFO 2007 (IOS Press, Netherlands and HISA Ltd. Australia) P125 p.1086-1100 (2007.8)

Tanaka S, Mahmut Y, Mogushi K, Aihara A, Kudo A, Nakamura N, Ito K, Imoto I, Inazawa J, Miki Y, Mizushima H, Tanaka H, Arii S. ; Omics analysis to predict the aggressive recurrence of hepatocellular carcinoma after curatve hepatectomy. Proceedings of Annual Meeting of the Japanese Cancer Association p.225 (2007.10)

Ohashi W, Mogushi K, Mizushima H, Tanaka H., Efficient Clinical Trials for anticancer drugs by using the genomic Information Proceedings of Annual Meeting of the Japanese Cancer Association p.371 (2007.10)

Tanaka H, Arii S, Sugihara K, Miki Y, Inazawa J, Mizushima H. ; TMDU Clinical Omics Database - Integrating OMICS data and Clinical Information. Proceedings of Annual Meeting of the Japanese Cancer Association p.403 (2007.10)

Mogushi K, Mizushima H, Ohashi W, Tanaka H. ; PathwayMap: pathway-based evaluation and visualization software for microarray analysis Proceedings of Annual Meeting of the Japanese Cancer Association p.518(2007.10)

Mahmut Y, Mizushima H, Ohta T, Tanaka S, Arii S, Tanaka H. ; The significance of up-regulated Aurora B Kinase and alternative variant forms in Hepatocellular Carcinoma. Proceedings of Annual Meeting of the Japanese Cancer Association p.557 (2007.10)

Saeki N, Kim DH, Usui T, Aoyagi K, Tatsuta T, Aoki K, Yanagihara K, Tamura M, Mizushima H, Sakamoto H, Ogawa K, Ohki M, Shiroishi T, Yoshida T, Sasaki H. ; GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene. 26(45):p.6488-98. (2007.10) [Pubmed]

Nemoto S., Miyaguchi K., Mogushi K., Mahmut Y., Mizushima H, Tanaka S., Arii S., Tanaka H., ; Copy Number Analysis of Hepatocellular Carcinoma Using High-Resolution SNP Oligonucleotide Array. Proc. Ann. Conf. Jpn Soc. Bioinformatics. P042-1-2. (2007.12)

Kim H., Mahmut Y., Mogushi K., Nakahara I., Mizushima H, Ohta T., Hirokawa T., Tanaka H., ; Protein Structure Modeling of Aurora Kinase B Splicing Variants. Proc. Ann. Conf. Jpn Soc. Bioinformatics. P094-1-2. (2007.12)

Miyaguchi K., Mogushi K., Imamura T., Mizushima H, Takahashi K., Uzawa N., Amagasa T., Tanaka H. ; Whole-Genome Analysis of Copy Number Variations in Oral Cancer Using High-Density SNP Microarrays , GIW07 (2007.12)

Ohashi W, Mizushima H, Tanaka H., Economic advantage of pharmacogenomics - clinical trials with genetic information. Stud Health Technol Inform. 2008;136:585-90 (2008)[Pubmed]

Ohashi K., Sakamoto N., Watanabe M., Mizushima H, Tanaka H. Development of a Telediagnosis Endoscopy System over Secure Internet. Methods Inf Med. 2008;47(2):157-66 (2008)[Pubmed]

Mizushima H, Mahmut Y., Shimokawa K., Mogushi K, Miyaguchi K., Itoda M., Tanaka H. ; Clinical Omics Database System (iCOD), integrating clinical and molecular biological information. ISMB08 (2008.7)

Mizushima H, Mahmut Y., Nakaya J., Nishibori M., Shimokawa K., Mogushi K, Ohashi W, Miyaguchi K., Itoda M., Ayumi K., Araki E, Fujisaki A., Ishikawa T., Uzawa N., Miura M., Tanaka S., Shibuya H., Amagasa T., Sugihara K., Arii S, Inazawa J, Miki Y, Tanaka H. ; Establishment of Clinical Omics Database System by integrating clinical and molecular biological information. ECCB08 (2008.9)

Last Update: 081106, hmizushi@bioinfo.tmd.ac.jp